Conversion of racemic alcohols to optically pure amine precursors enabled by catalyst dynamic kinetic resolution: experiment and computation.

by Luis MigueláAzofra, Mai Anh Tran, Viktoriia Zubar, Luigi Cavallo, et.al.
Year: 2020 DOI: https://doi.org/10.1039/D0CC02881A

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Chem. Commun.

Abstract

An unprecedented base metal catalysed asymmetric synthesis of α-chiral amine precursors from racemic alcohols is reported. This redox-neutral reaction utilises a bench-stable manganese complex and Ellman's sulfinamide as a versatile ammonia surrogate. DFT calculations explain the unusual finding of the highly stereoselective transformation enabled by a catalyst that undergoes an unusual dynamic kinetic resolution.