Magnesium-Catalyzed Hydroboration of Terminal and Internal Alkynes

by Marc Magre, Bholanath Maity, Alban Falconnet, Luigi Cavallo, Magnus Rueping
Year: 2019 DOI:

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The German Chemical Society


A magnesium-catalyzed hydroboration of alkynes providing good yields and selectivities for a wide range of terminal and symmetrical and unsymmetrical internal alkynes has been developed. The compatibility with many functional groups makes this magnesium catalyzed procedure attractive for late stage functionalization. Experimental mechanistic investigations and DFT calculations reveal insights into the reaction mechanism of the magnesium catalyzed protocol.