The anticancer activity of an air-stable Pd(I)-NHC (NHC = N-heterocyclic carbene) dimer.

by Stefano Palazzolo, Isabella Caligiuri, Busra Dereli, Manoj V Mane, et.al.
Year: 2020 DOI: https://doi.org/10.1039/D0CC03883K

Extra Information

Chem. Commun.

Abstract

A new dinuclear Pd(I) complex coordinating two bis(NHC) ligands revealed an unsuspected stability despite the unsaturation of the two metal centres. Even more surprisingly, the compound showed high and selective antiproliferative activity against different cancer cell lines and ovarian cancer tumoroids, and the mechanism of action was different from that of cisplatin.